Conclusions:
- The FRI deposition profiles highlighted significant differences between the VHCs on test, with intrathoracic delivery for the AeroChamber Plus* Flow-Vu* VHC system being almost double that of the other two VHC systems and being similar to the MDI alone with perfect coordination.
- When a short 0.5 second inhalation delay with the MDI alone was modelled, the intrathoracic lung delivery decreased from 25.4 mcg to 0.3 mcg
- These results highlight that the use of an appropriate VHC should be considered as general practice for all MDI patients other than those with a highly proficient inhaler technique and that VHCs should not be considered interchangeable