Lab study evaluating medication delivery MDI alone vs new portable spacer  

RESULT: Portable spacer provides optimum delivery without need for inhalation coordination.

Summary:

Presented at DDL 2017 in Edinburgh

• Valved holding chambers are widely prescribed to assist patients receiving inhaled medications by avoiding losses caused by imperfect coordination of inhalation and actuation and also to reduce oropharyngeal deposition.
• Regardless of whether using a solution based formulation (like Qvar) or a suspension formulation (Flovent), the use of a valved holding chamber reduced the amount of medication deposited in the mouth (oropharynx) and increased the potential for lung delivery
• This study can be used to help demonstrate the value of using a valved holding chamber for both solution and suspension formulated metered dose inhalers and for all patient populations, including adults

Short-acting beta2 agonist (SABA) monotherapy is typically required to provide as needed short term relief of bronchoconstriction. The salbutamol EasyHaler† DPI has recently become available in the UK as an alternative to delivery by pressurized metered-dose inhaler. Our study evaluated delivery from this DPI at different inhalation flow rates.

As current MDIs contain hydrofluorocarbon propellants, it would be beneficial to find ways to reduce carbon emissions without compromising patient safety.

This lab study investigated a way to optimize the modelled lung dose per actuation while at the same time minimizing the carbon emissions from the MDI

Efficacy is a major aspect when selecting an OPEP device for airway clearance.

This study was presented at the North American Cystic Fibrosis Conference 2022.

Patient use & evaluations of Aerobika* device across 23 UK Centres

RESULT: Improved CAT scores, 92% patients continuing Tx, 87% HCP (very) happy.

Patient use & evaluations of Aerobika* device across 23 UK Centres

RESULT: Improved CAT scores, 92% patients continuing Tx, 87% HCP (very) happy.

Asthma control and global warming are important issues that have significant impacts on human health and the environment.

It is critical however to ensure that maintaining or improving the patient’s asthma control goes hand in hand with environmental actions.

This lab study investigated how to optimize the modelled lung delivery while at the same time minimizing the carbon emissions from the MDI.

The FRI deposition profiles highlighted significant differences between the VHCs on test, with intrathoracic delivery for the AeroChamber Plus* Flow-Vu* VHC system being almost double that of the other two VHC systems and being similar to the MDI alone with perfect coordination

Conclusion

• The delivery of medication from the AEROECLIPSE* II BAN* to the lungs was not affected by the incorporation of the Aerobika* OPEP device. Aerosol deposition within the lung was unaltered by the addition of the OPEP device as evidenced by the near identical percentage of the dose being deposited in both the peripheral and central airways.
• BAN+OPEP therapy could offer the clinician the opportunity for combined treatment thereby reducing the time needed for the patient to take both nebulizer and OPEP treatments separately.

More consistent dose delivery was achieved with the breath actuated technology rather than breath enhanced. Delivering medication only when the patient inhales would result in more stable therapy if I:E ratio was to change with disease< progression or if the patient took breaks to talk during treatment.

Does Spacer/Adapter Device Choice Affect Delivery of a Pressurized Metered Dose Inhaler (pMDI) through a Humidified Circuit to a Simulated Patient on Mecha

More consistent dose delivery was achieved with the breath actuated technology rather than breath enhanced.
Delivering medication only when the patient inhales would result in more stable therapy if I:E ratio was to change with disease< progression or if the patient took breaks to talk during treatment.

Living a full life with Chronic Obstructive Pulmonary Disease (COPD) is more accessible than ever before with today’s online resources. Whether you’re looking for in-depth tutorials, facts, or simple tips on self-management, the web offers information at your fingertips. Here’s a few of our favourite bookmark-worthy websites for you!

Medications to manage care of bronchiectasis and NTM patients are often delivered via a nebulizer. This study compares a number of different OPEP/Nebulizer combinations using salbutamol as the modelled medication.