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Breathing Simulator evaluation; Tidal volume=155-mL, I:E ratio=1:2, rate=25 cycles/min.
The facemask of each VHC (n=3) was attached to an anatomical model and the airway coupled to a breathing simulator via a filter to capture drug particles that penetrated as far as the carina.
5-actuations of salbutamol (Ventolin†) were delivered at 30-s intervals and recovered from specific locations in the aerosol pathway by HPLC.
Comparisons were then made on drug delivery data looking at potential dose to the lungs for each pMDI/spacer.
This potential delivery was then equated to a potential relative carbon footprint based upon published claims1 that Ventolin† has a carbon footprint of 28 kg CO2 per inhaler.
